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pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Check. Drugs that raise delta-aminolevulinic acid synthetase may lessen hemin effect.pentobarbital will lower the level or effect of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Recommended atogepant dos